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Cholera
toxin
Cell Culture
Reagents-Growth Supplements
Catalogue Number: CC104
Description: Toxin consisting of an A subunit (27 kDa) with five B subunits
(approximately 12 kDa each) surrounding, which attach the toxin to ganglioside
GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit
of the stimulatory G protein (Gαs), reducing GTPase activity and activating the
α-subunit. This activation of Gαs leads to an increase in the activity of
adenylyl cyclase, resulting in increased levels of cAMP. Cholera toxin has also
been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine
adjuvant, inducing T helper cell type 2 responses by inhibiting the production
of interleukin-12.
Physical Appearance: Sterile filtered clear solution.
Formulation: 50mg/ml
solution.
Pack Size: 1.0 mL
Stability: Stored at -20°C. Please avoid freeze-thaw
cycles.
Suitability: Cell culture tested.